Coutard M, Osborne-Pellegrin M
INSERM U 367, Paris, France.
Am J Pathol. 1992 Nov;141(5):1053-61.
The straight spermatic and highly convoluted testicular arteries were studied by light microscopy in adult and aging normotensive (NT) and spontaneously hypertensive (SHR) rats. In younger rats, on the internal part of bends of the testicular artery, areas lacking the media similar to classical cerebral arterial medial defects were observed. At the same location, in other bends, structurally defective areas (SDA) constituted by or including medial defects but also lacking the internal elastic lamina and which in some cases evaginated, were present. Structurally defective areas were less numerous in SHR than in NT rats at 6 months, suggesting that intrinsic differences may exist between rat strains. In contrast, in old rats, the number of SDA was higher in hypertensive than in normotensive rats, supporting the role of hemodynamics in SDA formation. With age, SDA enlarged in both rat strains, and most of them became structurally similar to aneurysms, ie, lacking the internal elastic lamina and medial cells and with a dilated lumen, supporting the view that medial defects are sites of aneurysmal structure development. In hypertensive rats, fibrin and lipid deposits occurred within these aneurysmal-like structures. In the straight part of the spermatic artery no such structural modifications occurred, suggesting that either hemodynamics and/or structural development, both dependent on arterial geometry, are determinant in SDA formation. The results are discussed in view of the use of the rat testicular artery as a possible model of the formation of spontaneous aneurysmal-like structures relevant to cerebral aneurysms.
在成年和老龄正常血压（NT）大鼠及自发性高血压（SHR）大鼠中，通过光学显微镜对精索直动脉和高度盘曲的睾丸动脉进行了研究。在年轻大鼠中，在睾丸动脉弯曲的内部部分，观察到缺乏中膜的区域，类似于经典的脑动脉中膜缺陷。在同一位置的其他弯曲处，存在由中膜缺陷构成或包括中膜缺陷但也缺乏内弹性膜且在某些情况下向外突出的结构缺陷区域（SDA）。在6个月大时，SHR大鼠中的结构缺陷区域比NT大鼠中的少，这表明大鼠品系之间可能存在内在差异。相反，在老年大鼠中，高血压大鼠的SDA数量高于正常血压大鼠，这支持了血流动力学在SDA形成中的作用。随着年龄的增长，两种大鼠品系中的SDA都增大，并且它们中的大多数在结构上变得类似于动脉瘤，即缺乏内弹性膜和中膜细胞且管腔扩张，这支持了中膜缺陷是动脉瘤样结构发育部位的观点。在高血压大鼠中，在这些动脉瘤样结构内出现了纤维蛋白和脂质沉积。在精索动脉的直部未发生此类结构改变，这表明依赖于动脉几何形状的血流动力学和/或结构发育在SDA形成中起决定性作用。鉴于将大鼠睾丸动脉用作与脑动脉瘤相关的自发性动脉瘤样结构形成的可能模型，对这些结果进行了讨论。
