Karaguezyan K G, Haroutjunian V M, Mamiconyan R S, Hakobian G S, Nazaretian E E, Hovsepyan L M, Hoveyan G A, Gevorkian E M, Hovakimyan S S, Zakarian A E, Quinn P J
Department of Bioinorganic Chemistry, Yerevan State Medical University, Republic of Armenia.
J Clin Pathol. 1996 Jun;49(6):453-5. doi: 10.1136/jcp.49.6.453.
Familial Mediterranean fever (FMF) is a genetically linked disorder common amongst races of the Eastern Mediterranean region. Typical symptoms include episodic pain syndrome extending throughout the chest or abdomen associated with histopathological signs of amyloidosis of the kidney.
To investigate possible connections between the aseptic inflammation that occurs during pain crises and cell membrane structural and functional integrity in patients with FMF.
Oxidative stress parameters in 42 patients in remission and during a pain crisis were compared with 21 normal subjects.
The patient group had significantly greater concentrations of chemiluminescent and thiobarbituric acid-reactive substances in the blood plasma and lower concentrations of alpha-tocopherol than the control group while in remission; these changes were exacerbated during pain crises. Analyses of the phospholipid composition of erythrocyte membranes showed significant increases in amounts of acidic phospholipids (phosphatidic acid, monophosphatidylinositol and cardiolipin) and lysophosphatidylcholine compared with healthy subjects.
The pattern of differences in membrane phospholipid composition was consistent with increased oxidative stress in patients with FMF.
家族性地中海热（FMF）是一种与基因相关的疾病，在东地中海地区的种族中很常见。典型症状包括遍及胸部或腹部的发作性疼痛综合征，并伴有肾脏淀粉样变性的组织病理学迹象。
研究FMF患者疼痛发作期间发生的无菌性炎症与细胞膜结构和功能完整性之间的可能联系。
将42例缓解期和疼痛发作期患者的氧化应激参数与21名正常受试者进行比较。
缓解期患者组血浆中化学发光物质和硫代巴比妥酸反应性物质的浓度明显高于对照组，而α-生育酚浓度低于对照组；这些变化在疼痛发作时加剧。红细胞膜磷脂组成分析显示，与健康受试者相比，酸性磷脂（磷脂酸、单磷脂酰肌醇和心磷脂）和溶血磷脂酰胆碱的含量显著增加。
膜磷脂组成的差异模式与FMF患者氧化应激增加一致。
