Krieg P H, Schipper I
Ophthalmology Clinic, Cantonal Hospital, Lucerne, Switzerland.
Eye (Lond). 1996;10 ( Pt 1):121-6. doi: 10.1038/eye.1996.21.
Drug-induced oedema of the ciliary body is rare, and occurs predominantly following exposure to sulphonamides. In a 31-year-old patient in her 37th week of pregnancy, we observed reversible myopia of -4.75 dioptres following the ingestion of chlorthalidone. In a second case report we describe, in a 61-year-old patient suffering from aspirin-sensitive asthma, recurrent ciliary body oedema with a marked spastic component which was triggered by the medications acetazolamide, dipivefrine and pilocarpine. We explain oedema of the ciliary body on the basis of the eicosanoids. We believe that the oedema is caused mainly by prostaglandins and that leucotrienes are predominantly responsible for the spastic component. We postulate a drug-induced elevation in eicosanoid concentrations, as well as certain interrelationships between ciliary body oedema and aspirin-sensitive asthma.
药物性睫状体水肿罕见，主要发生在接触磺胺类药物之后。在一名怀孕37周的31岁患者中，我们观察到其在服用氯噻酮后出现了-4.75屈光度的可逆性近视。在第二篇病例报告中，我们描述了一名患有阿司匹林敏感性哮喘的61岁患者，其睫状体水肿反复出现，并伴有明显的痉挛成分，这是由乙酰唑胺、地匹福林和毛果芸香碱等药物引发的。我们基于类花生酸来解释睫状体水肿。我们认为水肿主要由前列腺素引起，而白三烯主要负责痉挛成分。我们推测药物会导致类花生酸浓度升高，以及睫状体水肿与阿司匹林敏感性哮喘之间存在某些相互关系。
