Shinkwin C A, Murty G E, Simo R, Jones N S
Department of Otolaryngology, University Hospital, Nottingham, UK.
J Laryngol Otol. 1996 Jun;110(6):531-3. doi: 10.1017/s0022215100134188.
The per-operative instillation of ototopical antibiotic/steroid drops reduces the incidence of early otorrhoea after tympanostomy tube insertion. Whether this is due to the chemical properties of the antibiotic/steroid or simply the mechanical instillation of fluid is unclear. In this paired matched study of 161 subjects Gentisone HC was shown to significantly reduce the otorrhoea rate compared to normal saline (1.24 per cent compared with 9.32 per cent, p < 0.005, difference 8.07 per cent, 95 per cent confidence interval for difference 3.21 per cent to 12.93 per cent). Capillary viscosimetry proved Gentisone HC to be more viscous than normal saline. The benefits are due to Gentisone HC's chemical properties, and Gentisone HC rather than normal saline instillation per-operatively is recommended when tympanostomy tubes are inserted.
鼓膜置管术中局部滴入耳用抗生素/类固醇滴眼液可降低术后早期耳漏的发生率。目前尚不清楚这是由于抗生素/类固醇的化学性质，还是仅仅因为液体的机械滴入。在这项针对161名受试者的配对对照研究中，与生理盐水相比，氢化可的松庆大霉素（Gentisone HC）显著降低了耳漏发生率（分别为1.24%和9.32%，p<0.005，差异为8.07%，差异的95%置信区间为3.21%至12.93%）。毛细管粘度测定法证明氢化可的松庆大霉素比生理盐水更粘稠。这些益处归因于氢化可的松庆大霉素的化学性质，因此建议在鼓膜置管术时术中滴入氢化可的松庆大霉素而非生理盐水。
