De Berker D, Mawhinney B, Sviland L
Department of Dermatology, Royal Victoria Infirmary, Newcastle upon Tyne, U.K.
Br J Dermatol. 1996 Jun;134(6):1083-6.
The relative nail producing capacity of different regions within the nail matrix has not been quantified. In order to do this, the number of nail plate cells in the dorsoventral axis of 12 human great toenails was counted at five sites in the longitudinal axis, and compared with direct measurements of nail plate thickness at the same sites. The mean number of nail cells in the nail plate reached a maximum at the lunula, with no further increase along the length of the nail bed. At the mid-point between the proximal tip of the germinal matrix and lunula, mean cell numbers achieved 81% of the value at the lunula. Mean nail thickness was only 90% of its maximum at the lunula, with a further significant increase (P = 0.02) between the lunula and end of the nail bed. These observations suggest that the proximal nail matrix is the main source of nail within the matrix. This is consistent with clinical experience where distal matrix surgery has a low potential for scarring in comparison with proximal matrix surgery. The additional finding of increased nail thickness, but not cell numbers, along the nail bed make it likely that cells within the nail plate change shape as they move distally.
甲母质内不同区域产生指甲的相对能力尚未被量化。为了做到这一点，在12个人类大脚趾指甲纵轴上的五个部位，对其背腹轴上的甲板细胞数量进行了计数，并与相同部位甲板厚度的直接测量结果进行了比较。甲板中的指甲细胞平均数在甲半月处达到最大值，沿甲床长度不再增加。在生发基质近端尖端与甲半月的中点处，平均细胞数达到甲半月处数值的81%。平均指甲厚度在甲半月处仅为其最大值的90%，在甲半月与甲床末端之间有进一步显著增加（P = 0.02）。这些观察结果表明，近端甲母质是甲母质内指甲的主要来源。这与临床经验一致，即与近端甲母质手术相比，远端甲母质手术形成瘢痕的可能性较低。沿着甲床出现指甲厚度增加但细胞数量未增加这一额外发现，使得甲板内的细胞在向远端移动时可能会改变形状。
