生命早期脑电功率谱的遗传结构
Genetic architecture of EEG power spectra in early life.
作者信息
Van Baal G C, De Geus E J, Boomsma D I
机构信息
Department of Psychophysiology, Vrije Universiteit, De Boelelaan, Amsterdam, The Netherlands.
出版信息
Electroencephalogr Clin Neurophysiol. 1996 Jun;98(6):502-14. doi: 10.1016/0013-4694(96)95601-1.
We measured the electroencephalogram (EEG) in 209 5 year old monozygotic (MZ) and dizygotic (DZ) twin pairs to estimate the relative contribution of genetic and environmental factors to EEG power spectra in early life. Data from same-sex and from opposite-sex twin pairs were used to test for sex differences in genetic influences. Results showed high concordance for EEGs of MZ twins for absolute and relative power in delta, theta, alpha 1, alpha 2, beta 1 and beta 2 bands. A model with additive genetic and unique environmental influences explained individual differences in both absolute and relative power in almost all bands and all electrode positions. Heritability of EEG power spectra was high. For absolute power the highest heritabilities were observed in theta, alpha 1, alpha 2 and beta 1 power bands (mean heritability 81, 81, 78, and 73%, respectively). Somewhat lower heritabilities were found in delta and beta 2 bands (mean heritability 55 and 64%, respectively). For relative power heritabilities were 63, 76, 71, 72, 68, and 65 for delta, theta, alpha 1, alpha 2, beta 1, and beta 2, respectively. Virtually no sex differences in heritability were found. These findings indicate that the background EEG is one of the most heritable characteristics in early life.
我们对209对5岁的同卵（MZ）和异卵（DZ）双胞胎进行了脑电图（EEG）测量，以评估遗传和环境因素对生命早期EEG功率谱的相对贡献。来自同性和异性双胞胎的数据用于测试遗传影响中的性别差异。结果显示，MZ双胞胎在δ、θ、α1、α2、β1和β2频段的绝对功率和相对功率的EEG具有高度一致性。一个具有加性遗传和独特环境影响的模型解释了几乎所有频段和所有电极位置的绝对功率和相对功率的个体差异。EEG功率谱的遗传度很高。对于绝对功率，在θ、α1、α2和β1功率频段观察到最高的遗传度（平均遗传度分别为81%、81%、78%和73%）。在δ和β2频段发现的遗传度略低（平均遗传度分别为55%和64%）。对于相对功率，δ、θ、α1、α2、β1和β2的遗传度分别为63%、76%、71%、72%、68%和65%。几乎没有发现遗传度存在性别差异。这些发现表明，背景EEG是生命早期最具遗传性的特征之一。
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