Ferreira A, Fernando P M, Cortez M, Capucho R, Brandão F, Gomes M C
Servico de Medicina 3, Hospital de São João, Porto.
Rev Port Cardiol. 1996 May;15(5):395-410, 364-5.
The aim of this study was to characterise the epidemiology of congestive heart failure namely assessing demographic, etiologic and prognostic aspects, and the hospital admission trends in the last 6 years.
Retrospective analysis of computerised data concerning patients with congestive heart failure admitted to the department of Internal Medicine.
A central hospital in the North of Portugal.
Two thousand five hundred and sixty-one patients older than 10 years, admitted to the Internal Medicine Department of a central hospital in the North of Portugal between January 1, 1989 and December 31, 1994 and discharged with the principal or first listed diagnosis of congestive heart failure (ICD-9-CM code 4280).
Eighty per cent of the patients had more than 60 years of age and the mean age was 69 years (female: 70.40 +/- 12.65; male: 66.24 +/- 12.25; p < 0.0001). Fifty-four per cent were females and 46 per cent males. The prevalence of congestive heart failure in the Internal Medicine Department was 4.8%. Between the ages of 15 and 44 years the hospital age-specific prevalence was between 16.1/10,000/year and 26.7/10,000/year for women and between 14.5/10,000/year and 16.1/10,000/year for men. For ages equal or greater than 75 years it was between 508.9/10,000/year and 561.3/10,000/year for women and between 300.2/10,000/year and 421.8/10,000/year for men. Possible causes of congestive heart failure were: valve disease in 26 per cent of patients, coronary artery disease in 24 per cent and hypertension in 20 per cent. The average case-fatality rate was 15.15% (female: 15.54%; male: 14.69%; chi 2 = 0.36; p > 0.55) evolving from 19.45% in 1989 to 12.59% in 1994 (chi 2 = 6.85; p < 0.01). Between the ages of 15 and 44 years the hospital cause-specific mortality rate was 16.2/100,000 and for ages equal or greater than 75 years it was 743.6/100,000. Stepwise logistic regression produced the following odds ratios for the variables significantly associated with dead during hospital admission: age (> or = 70 years)--1.48; infectious diseases--1.37; central nervous system diseases--2.28; chronic renal diseases--1.96; cardiac arrest--24.1; pulmonary embolism--2.26; acute renal failure--7.93; clinical signs of severe sodium and water retention--1.49; hyponatremia--3.39; other electrolyte abnormalities and acid-base balance disturbances--1.78. The simple linear regression of daily admissions on time produced a positive slope of 0.0002 (p < 0.002).
The hospital prevalence of congestive heart failure is identical to other Western countries and is greater among the elderly patients. Valve disease, coronary artery disease and hypertension are the most frequent causes of congestive heart failure. An increasing trend in hospital admissions for congestive heart failure was observed. The hospital mortality was reduced in the last 6 years and was greater among the elderly patients. Age (> or = 70 years), the presence of comorbidity (infectious disease, central nervous system disease, acute renal failure, chronic renal disease and pulmonary embolism), hyponatremia, other electrolyte abnormalities and acid-base balance disturbances, resuscitated cardiac arrest and the presence of severe sodium and water retention have prognostic significance.
本研究旨在描述充血性心力衰竭的流行病学特征,即评估人口统计学、病因学和预后方面,以及过去6年的住院趋势。
对内科收治的充血性心力衰竭患者的计算机化数据进行回顾性分析。
葡萄牙北部的一家中心医院。
1989年1月1日至1994年12月31日期间,葡萄牙北部一家中心医院内科收治的2561例年龄大于10岁的患者,出院时主要诊断或首个诊断为充血性心力衰竭(国际疾病分类第九版临床修订本代码4280)。
80%的患者年龄超过60岁,平均年龄为69岁(女性:70.40±12.65;男性:66.24±12.25;p<0.0001)。女性占54%,男性占46%。内科充血性心力衰竭的患病率为4.8%。15至44岁年龄段,女性的医院年龄别患病率为每年16.1/10000至26.7/10000,男性为每年14.5/10000至16.1/10000。75岁及以上年龄段,女性为每年508.9/10000至561.3/10000,男性为每年300.2/10000至421.8/10000。充血性心力衰竭的可能病因如下:26%的患者为瓣膜病,24%为冠状动脉疾病,20%为高血压。平均病死率为15.15%(女性:15.54%;男性:14.69%;卡方检验=0.36;p>0.55),从1989年的19.45%降至1994年的12.59%(卡方检验=6.85;p<0.01)。在15至44岁年龄段,医院病因别死亡率为16.2/100000,75岁及以上年龄段为743.6/100000。逐步逻辑回归得出以下与住院期间死亡显著相关变量的比值比:年龄(≥70岁)——1.48;传染病——1.37;中枢神经系统疾病——2.28;慢性肾病——1.96;心脏骤停——24.1;肺栓塞——2.26;急性肾衰竭——7.93;严重钠水潴留的临床体征——1.49;低钠血症——3.39;其他电解质异常和酸碱平衡紊乱——1.78。每日入院人数随时间的简单线性回归得出正斜率为0.0002(p<0.002)。
充血性心力衰竭的医院患病率与其他西方国家相同,且在老年患者中更高。瓣膜病、冠状动脉疾病和高血压是充血性心力衰竭最常见的病因。观察到充血性心力衰竭的住院人数呈上升趋势。过去6年医院死亡率有所降低,且在老年患者中更高。年龄(≥70岁)、合并症(传染病、中枢神经系统疾病、急性肾衰竭、慢性肾病和肺栓塞)、低钠血症、其他电解质异常和酸碱平衡紊乱、复苏后心脏骤停以及严重钠水潴留的存在具有预后意义。