卡介苗接种后发生的狼疮样结核。一种罕见的疫苗接种并发症
[Tuberculosis lupus after BCG vaccination. A rare complication of the vaccination].
作者信息
Vittori F, Groslafeige C
机构信息
Département de médecine polyvalente, hôpital Saint-Jean-de-Dieu, Lyon, France.
出版信息
Arch Pediatr. 1996 May;3(5):457-9. doi: 10.1016/0929-693x(96)86404-9.
BACKGROUND
Cutaneous reactions to BCG have rarely been a problem and BCG is one of the safest vaccines in use.
CASE REPORT
Two children, 6 and 7 years old, developed local tuberculosis lupus 7 and 8 months, respectively, after BCG vaccination. Cutaneous changes cured after a treatment with isoniazid for 9 months in one case with observance of the treatment was uncertain in the other.
CONCLUSION
Tuberculosis lupus is a rare complication of BCG vaccination. Its clinical features are identical to those of the vulgaris lupus. The diagnosis is based on clinical, pathology aspects and anamnesia. This complication should not be a contra-indication of BCG immunization.
背景
卡介苗（BCG）的皮肤反应很少成为问题，并且卡介苗是正在使用的最安全的疫苗之一。
病例报告
两名儿童，分别为6岁和7岁，在接种卡介苗后7个月和8个月分别发生了局部结核性狼疮。其中1例经异烟肼治疗9个月后皮肤病变治愈，另一例在坚持治疗的情况下病情转归尚不确定。
结论
结核性狼疮是卡介苗接种的一种罕见并发症。其临床特征与寻常狼疮相同。诊断基于临床、病理方面及既往史。这种并发症不应成为卡介苗免疫接种的禁忌证。
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