Kigawa Tadayuki, Kawai Mayu, Yamaoka Hanako, Kondoh Akio, Tojo Masahiro, Mabuchi Tomotaka
Department of Dermatology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.
Tokai J Exp Clin Med. 2020 Sep 20;45(3):136-138.
In recent years, BCG vaccination is routinely performed worldwide. The Ministry of Health, Labor and Welfare of Japan reported that the vaccination rate was as high as 92.9% in 2011. Majority of the reported local adverse reactions to BCG vaccination included lymph node swelling, keloid formation, and abscesses. Subcutaneous tuberculous granuloma is a rare local adverse reaction to BCG vaccination. Herein, we report two cases of developing subcutaneous tuberculous granuloma associated with BCG vaccination. Both of them were treated with isoniazid. There is no standard management for BCG-induced subcutaneous tuberculous granuloma, however, treatment with anti-tuberculosis drugs should be considered for cases of BCGinduced subcutaneous tuberculous granuloma with abscesses or ulcerations.
近年来，卡介苗接种在全球范围内常规进行。日本厚生劳动省报告称，2011年的接种率高达92.9%。报告的卡介苗接种局部不良反应多数包括淋巴结肿大、瘢痕疙瘩形成和脓肿。皮下结核性肉芽肿是卡介苗接种罕见的局部不良反应。在此，我们报告两例与卡介苗接种相关的皮下结核性肉芽肿病例。两例均接受异烟肼治疗。对于卡介苗引起的皮下结核性肉芽肿尚无标准的治疗方法，然而，对于伴有脓肿或溃疡的卡介苗引起的皮下结核性肉芽肿病例，应考虑使用抗结核药物治疗。
