Okunieff P, Wu T, Huang K, Ding I
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Br J Cancer Suppl. 1996 Jul;27:S105-8.
Recently we found that human recombinant basic fibroblast growth factor (FGF2) radioprotected C3H/HeNCr mice after whole body irradiation (WBI). The purpose of the present study was to compare the in vivo radioprotective effects of human recombinant acidic fibroblast growth factor (FGF1) or FGF2 in three strains of mice (C3H/HeNCr, BALB/CAn, C57BL/6). In vivo administration of 6 micrograms/mouse of FGF1 or FGF2 pre- or post- WBI significantly protected only C3H and BALB/C mice. Dose modification factor was: C3H(FGF1/2) 1.09 +/- 0.02/1.14 +/- 0.04; BALB/C(FGF1/2) 1.13 +/- 0.02/1.15 +/- 0.01. Response was minimal or absent in C57 mice (FGF2 1.02 +/- 0.02). Increasing the FGF dose above 12 micrograms/mouse did not increase radioprotection in any strain. In single radiation dose studies, FGF2 was more potent than FGF1 in C3H mice; FGF1 and FGF2 were equipotent in BALB/C mice; and both had minimal effect in C57 mice. Significant radioprotection occurred in only two of the three strains of mice studied. We therefore suggest caution in applying mouse radioprotection data to other species.
最近我们发现，人重组碱性成纤维细胞生长因子（FGF2）在全身照射（WBI）后可对C3H/HeNCr小鼠起到辐射防护作用。本研究的目的是比较人重组酸性成纤维细胞生长因子（FGF1）或FGF2在三种品系小鼠（C3H/HeNCr、BALB/CAn、C57BL/6）中的体内辐射防护效果。在WBI前或后给每只小鼠体内注射6微克的FGF1或FGF2，仅对C3H和BALB/C小鼠有显著的保护作用。剂量修正因子为：C组（FGF1/2）1.09±0.02/1.14±0.04；BALB/C组（FGF1/2）1.13±0.02/1.15±0.01。C57小鼠的反应极小或无反应（FGF2为1.02±0.02）。将FGF剂量增加到每只小鼠12微克以上，对任何品系都没有增加辐射防护效果。在单次辐射剂量研究中，FGF2在C3H小鼠中比FGF1更有效；FGF1和FGF2在BALB/C小鼠中效果相当；而在C57小鼠中二者作用都极小。在所研究的三种品系小鼠中，只有两种出现了显著的辐射防护作用。因此，我们建议在将小鼠辐射防护数据应用于其他物种时要谨慎。
