McCoy C L, McIntyre D J, Robinson S P, Aboagye E O, Griffiths J R
Biochemistry Department, St. George's Hospital Medical School, London, UK.
Br J Cancer Suppl. 1996 Jul;27:S226-31.
It is well known that low levels of tissue oxygen (pO2) protect tumour cells from ionising radiation and some chemotherapeutic agents. Thus, numerous studies have been aimed at developing methods to measure tissue oxygenation. An initial discussion of some of the traditional methods for measuring oxygenation is included, followed by a discussion of magnetic resonance spectroscopy (MRS) and magnetic resonance imaging (MRI) methods for measuring tumour and normal tissue oxygenation. The latter methods are of interest because of the non-invasive nature of magnetic resonance (MR). Some of the MR methods described herein include: 31P MRS, 1H MRS and MRI, and 19F MRS and MRI. Each method is detailed, including a brief assessment of its ability to measure tumour oxygenation and its potential for clinical application.
众所周知，低水平的组织氧分压（pO2）可保护肿瘤细胞免受电离辐射和某些化疗药物的影响。因此，众多研究致力于开发测量组织氧合的方法。本文首先讨论了一些传统的氧合测量方法，随后探讨了用于测量肿瘤和正常组织氧合的磁共振波谱（MRS）和磁共振成像（MRI）方法。由于磁共振（MR）具有非侵入性，后一种方法备受关注。本文所述的一些MR方法包括：31P MRS、1H MRS和MRI，以及19F MRS和MRI。每种方法都有详细介绍，包括对其测量肿瘤氧合能力及其临床应用潜力的简要评估。
