Gerweck L E, Koutcher J, Zaidi S T
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, USA.
Acta Oncol. 1995;34(3):335-8. doi: 10.3109/02841869509093985.
Under full nutrient in vitro conditions, the cellular adenylate energy charge of six different rodent and human tumor cell types was identical, i.e., 0.94 +/- 0.01, suggesting the potential utility of this parameter as a cell (and tissue) independent marker of nutrient deprivation and hypoxia, across tumor types. The adenylate energy charge values of tumors, arising from these cells, was reduced and variable ranging from 0.72 to 0.91 for the various tumor types. However, neither the tumor adenylate energy charge, NTP/Pi, nor PCr/Pi ratios correlated with the radiobiologic hypoxic cell fractions across tumor types. The reduced adenylate energy charge in vivo suggests varying degrees of nutrient deprivation in the different tumor types, however, factors other than or in addition to hypoxia likely contribute to tumor energy status.
在完全营养的体外条件下，六种不同的啮齿动物和人类肿瘤细胞类型的细胞腺苷酸能荷相同，即0.94±0.01，这表明该参数有可能作为跨肿瘤类型的营养剥夺和缺氧的细胞（和组织）独立标志物。由这些细胞产生的肿瘤的腺苷酸能荷值降低且各不相同，不同肿瘤类型的范围为0.72至0.91。然而，肿瘤腺苷酸能荷、NTP/Pi或PCr/Pi比值与跨肿瘤类型的放射生物学乏氧细胞分数均无相关性。体内腺苷酸能荷降低表明不同肿瘤类型存在不同程度的营养剥夺，然而，除缺氧之外或之外的其他因素可能对肿瘤能量状态有影响。
