Agwunobi J, Abedin M, Young M, Beeram M, Sinkford S
District of Columbia General Hospital, Washington, DC 20003, USA.
J Natl Med Assoc. 1996 Jul;88(7):450-2.
Methylxanthine use in the treatment of apnea of prematurity is well documented. This drug is avoided in patients with aberrant pathways of conduction such as Wolff-Parkinson-White syndrome. In theory, methylxanthines enhance precipitation and exacerbation of tachyarrhythmias to which these patients are predisposed. This article reports a case of Wolff-Parkinson-White syndrome in a preterm neonate with severe apneic episodes in which methylxanthines were used. However, no adverse effects on cardiac rate or rhythm were encountered.
甲基黄嘌呤用于治疗早产儿呼吸暂停已有充分的文献记载。对于有异常传导通路的患者,如预激综合征患者,应避免使用这种药物。理论上,甲基黄嘌呤会增加这些患者易患的快速心律失常的发生率并使其加重。本文报道了一例患有严重呼吸暂停发作的早产儿预激综合征病例,该病例使用了甲基黄嘌呤。然而,未发现对心率或心律有不良影响。