al-Omran A, al-Alaiyan S
Department of Pediatrics, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Am J Perinatol. 1997 Mar;14(3):147-9. doi: 10.1055/s-2007-994116.
Steady-state serum theophylline concentrations following equal doses of intravenous aminophylline and oral theophylline were compared in 30 preterm infants with gestational age of 29.2 +/- 2.9 weeks. The result showed no significant statistical difference between the mean serum concentration of theophylline (8.2 +/- 2.2 micrograms/mL vs. 8.4 +/- 1.9 micrograms/mL; p = 0.483). This indicates that a dose reduction of 20%, which is currently recommended, is not required when changing from intravenous aminophylline to oral theophylline. We conclude that in preterm infants, equal doses of intravenous aminophylline and oral theophylline maintain the same serum theophylline concentration.
在30名胎龄为29.2±2.9周的早产儿中，比较了静脉注射氨茶碱和口服茶碱等量剂量后的稳态血清茶碱浓度。结果显示，茶碱的平均血清浓度之间无显著统计学差异（8.2±2.2微克/毫升对8.4±1.9微克/毫升；p = 0.483）。这表明，从静脉注射氨茶碱改为口服茶碱时，目前建议的20%剂量减少是不必要的。我们得出结论，在早产儿中，静脉注射氨茶碱和口服茶碱等量剂量可维持相同的血清茶碱浓度。
