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大量维拉帕米过量并伴有非心源性肺水肿。

Massive verapamil overdose complicated by noncardiogenic pulmonary edema.

作者信息

Brass B J, Winchester-Penny S, Lipper B L

机构信息

Department of Medicine, New York University Medical Center, NY 10016, USA.

出版信息

Am J Emerg Med. 1996 Sep;14(5):459-61. doi: 10.1016/S0735-6757(96)90151-5.

DOI:10.1016/S0735-6757(96)90151-5
PMID:8765109
Abstract

We describe two cases of pulmonary edema, bradycardia, and hypotension associated with massive verapamil overdose. A noncardiogenic etiology of the pulmonary edema was indicated in one patient by normal thermodilution cardiac output and pulmonary artery occlusion pressure, and in the other patient by a normal echocardiogram. We hypothesize that calcium channel blocker overdose predisposes patients to develop pulmonary edema.

摘要

我们描述了两例与维拉帕米大量过量相关的肺水肿、心动过缓和低血压病例。在一名患者中,热稀释法测得的心输出量和肺动脉闭塞压正常,提示肺水肿的病因是非心源性的;在另一名患者中,超声心动图正常也提示了这一点。我们推测,钙通道阻滞剂过量使患者易发生肺水肿。

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1
Massive verapamil overdose complicated by noncardiogenic pulmonary edema.大量维拉帕米过量并伴有非心源性肺水肿。
Am J Emerg Med. 1996 Sep;14(5):459-61. doi: 10.1016/S0735-6757(96)90151-5.
2
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Massive overdose of sustained-release verapamil: a case report and review of literature.缓释维拉帕米大量过量:一例病例报告及文献综述
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Acute respiratory distress syndrome following verapamil overdose treated with intravenous lipid emulsion: a rare life-threatening complication.静脉注射脂质乳剂治疗维拉帕米过量后发生的急性呼吸窘迫综合征:一种罕见的危及生命的并发症。
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Non-cardiogenic pulmonary edema and life-threatening shock due to calcium channel blocker overdose: a case report and clinical review.钙通道阻滞剂过量致非心源性肺水肿和危及生命的休克:病例报告和临床复习。
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Calcium channel blocker overdose.钙通道阻滞剂过量。
Am J Emerg Med. 1995 Jul;13(4):444-50. doi: 10.1016/0735-6757(95)90137-X.

引用本文的文献

1
Severe Noncardiogenic Pulmonary Edema Secondary to Massive Verapamil Overdose and Treatment with Venovenous Extracorporeal Membrane Oxygenation.维拉帕米大量过量继发严重非心源性肺水肿及静脉-静脉体外膜肺氧合治疗
Case Rep Crit Care. 2020 Dec 24;2020:8842303. doi: 10.1155/2020/8842303. eCollection 2020.
2
K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport.钾通道开放剂恢复维拉帕米抑制的肺液清除和跨上皮离子转运。
Respir Res. 2010 May 27;11(1):65. doi: 10.1186/1465-9921-11-65.
3
[Seizure and non-cardiogenic pulmonary edema after intoxication].
[中毒后癫痫发作与非心源性肺水肿]
Internist (Berl). 2010 Apr;51(4):528-32. doi: 10.1007/s00108-009-2544-2.
4
Vasopressin treatment of verapamil toxicity in the porcine model.血管加压素治疗猪模型中维拉帕米中毒
J Med Toxicol. 2005 Dec;1(1):3-10. doi: 10.1007/BF03160898.
5
Management of calcium channel antagonist overdose.钙通道拮抗剂过量的处理
Drug Saf. 2003;26(2):65-79. doi: 10.2165/00002018-200326020-00001.