Prager E M, Jollès P
Division of Biochemistry and Molecular Biology, University of California, Berkeley 94720-3202, USA.
EXS. 1996;75:9-31. doi: 10.1007/978-3-0348-9225-4_2.
Amino acid sequences for 88 distinct lysozymes c, obtained from members of four vertebrate classes and two orders of insects, are summarized. A model for the relationships and origins of major lineages within the lysozyme c superfamily-which consists of conventional lysozymes c, calcium-binding lysozymes c, and alpha-lactalbumin-is presented and supported by evolutionary analyses. Pioneering events in the discovery and sequencing of lysozymes c are traced, and salient contributions to knowledge made by sequences from various kinds of animals highlighted. A summary of the four known amino acid sequences of bird lysozymes g and an outline of the investigations on this very different kind of vertebrate lysozyme are provided. Areas of future research aimed at further elucidating early events in the evolutionary history of the lysozyme c superfamily and at understanding differences in patterns of lysozyme gene expression are outlined.
总结了从四类脊椎动物和两类昆虫成员中获得的88种不同溶菌酶c的氨基酸序列。提出了一个关于溶菌酶c超家族主要谱系的关系和起源的模型，该超家族由传统溶菌酶c、钙结合溶菌酶c和α-乳白蛋白组成，并得到了进化分析的支持。追溯了溶菌酶c发现和测序中的开创性事件，并强调了来自各种动物的序列对知识的突出贡献。提供了鸟类溶菌酶g的四个已知氨基酸序列的总结以及对这种非常不同的脊椎动物溶菌酶的研究概述。概述了未来的研究领域，旨在进一步阐明溶菌酶c超家族进化历史中的早期事件，并了解溶菌酶基因表达模式的差异。
