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Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.

作者信息

Muller G W, Corral L G, Shire M G, Wang H, Moreira A, Kaplan G, Stirling D I

机构信息

Celgene Corporation, Warren, New Jersey 07059, USA.

出版信息

J Med Chem. 1996 Aug 16;39(17):3238-40. doi: 10.1021/jm9603328.

DOI:10.1021/jm9603328
PMID:8765505
Abstract
摘要

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1
Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity.沙利度胺的结构修饰产生了具有增强肿瘤坏死因子抑制活性的类似物。
J Med Chem. 1996 Aug 16;39(17):3238-40. doi: 10.1021/jm9603328.
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Potent inhibition of tumor necrosis factor-alpha production by tetrafluorothalidomide and tetrafluorophthalimides.四氟沙利度胺和四氟邻苯二甲酰亚胺对肿瘤坏死因子-α 产生的强效抑制作用。
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Enhanced potency of perfluorinated thalidomide derivatives for inhibition of LPS-induced tumor necrosis factor-alpha production is associated with a change of mechanism of action.全氟沙利度胺衍生物抑制脂多糖诱导的肿瘤坏死因子-α产生的效力增强与作用机制的改变有关。
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Cell type-/inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-alpha production and its enantio-dependence.
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Inducer-specific bidirectional regulation by thalidomide and phenylphthalimides of tumor necrosis factor-alpha production.
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Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide.与沙利度胺结构相关的新型邻苯二甲酰亚胺衍生物的设计、合成及抗炎活性
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Tumor necrosis factor alpha production enhancers with a phenylphthalimide skeleton.
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Thalidomide metabolites and analogues. 3. Synthesis and antiangiogenic activity of the teratogenic and TNFalpha-modulatory thalidomide analogue 2-(2,6-dioxopiperidine-3-yl)phthalimidine.
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