Harraki B, Guiraud P, Rochat M H, Alary J, Favier A
Laboratoire de Biochimie C, Hôpital A. Michallon, Grenoble, France.
Pharm Acta Helv. 1995 Dec;70(4):269-78. doi: 10.1016/0031-6865(95)00034-8.
Trace elements (TE) are now commonly added into the nutritive admixtures used in total parenteral nutrition (TPN) to prevent deficiencies which can be observed in patients undergoing long-term intravenous feeding. Although the needs in TE are not exactly known during a TPN, some of them must be considered as essential according to the results of studies dealing with general nutritional deficiencies. Among essential TE copper, iron and zinc are found at relatively high levels in organism. Chromium, manganese and selenium are also very important even though they are present at lower levels. In the case of a parenteral nutrition, the composition of the mixture is precisely defined and both digestion and absorption steps are shunted. Nevertheless, beneficial and/or negative physicochemical and metabolic interactions can occur between TE and the other nutrients. These interactions must be studied and taken into account because they can modify the bioavailability of the trace elements. In this article, our aim is to review the main recent bodies of knowledge which could be helpful to understand and prevent nutritional problems linked to these interactions during parenteral nutrition.
微量元素（TE）现在通常被添加到全胃肠外营养（TPN）中使用的营养混合液中，以预防长期静脉营养患者可能出现的缺乏症。虽然在TPN期间对微量元素的需求尚不完全清楚，但根据有关一般营养缺乏症的研究结果，其中一些必须被视为必需元素。在必需微量元素中，铜、铁和锌在机体中含量相对较高。铬、锰和硒虽然含量较低，但也非常重要。在胃肠外营养的情况下，混合液的成分是精确确定的，消化和吸收步骤均被绕过。然而，微量元素与其他营养素之间可能会发生有益和/或负面的物理化学和代谢相互作用。必须研究并考虑这些相互作用，因为它们会改变微量元素的生物利用度。在本文中，我们的目的是综述近期的主要知识体系，这些知识可能有助于理解和预防胃肠外营养期间与这些相互作用相关的营养问题。
