一系列作为鼠伤寒沙门氏菌TA98诱变剂的芳香族硝基化合物中的形状依赖性效应。
Shape-dependent effects in a series of aromatic nitro compounds acting as mutagenic agents on S. typhimurium TA98.
作者信息
Caliendo G, Fattorusso C, Greco G, Novellino E, Perissutti E, Santagada V
机构信息
Dipartimento di Chimica Farmaceutica e Tossicologica, Universitä degli Studi di Napoli Federico II, Naples (Italy).
出版信息
SAR QSAR Environ Res. 1995;4(1):21-7. doi: 10.1080/10629369508234011.
PMID:8765901
Abstract
The steric properties modulating the mutagenic activity on S. typhimurium TA98 of a set of nitroaromatic compounds have been investigated using the CoMFA method. In addition to steric probe-ligand interaction energies, the overall lipophilicity and the energy of the lowest occupied molecular orbital have been employed as molecular descriptors.
摘要
已使用比较分子场分析法（CoMFA）研究了一组硝基芳香族化合物对鼠伤寒沙门氏菌TA98致突变活性的空间性质调控。除了空间探针 - 配体相互作用能外，整体亲脂性和最低未占分子轨道的能量也已用作分子描述符。
相似文献
1
Shape-dependent effects in a series of aromatic nitro compounds acting as mutagenic agents on S. typhimurium TA98.一系列作为鼠伤寒沙门氏菌TA98诱变剂的芳香族硝基化合物中的形状依赖性效应。
SAR QSAR Environ Res. 1995;4(1):21-7. doi: 10.1080/10629369508234011.
2
LUMO energies and hydrophobicity as determinants of mutagenicity by nitroaromatic compounds in Salmonella typhimurium.最低未占分子轨道能量和疏水性作为鼠伤寒沙门氏菌中硝基芳香族化合物致突变性的决定因素。
Environ Mol Mutagen. 1990;15(1):44-55. doi: 10.1002/em.2850150107.
3
Quantitative structure-activity relationships and COMPACT analysis of a series of food mutagens.一系列食品诱变剂的定量构效关系及COMPACT分析
Food Addit Contam. 1995 Sep-Oct;12(5):715-23. doi: 10.1080/02652039509374361.
4
Mutagenicity of nitro- and amino-substituted carbazoles in Salmonella typhimurium. III. Methylated derivatives of 9H-carbazole.硝基和氨基取代咔唑在鼠伤寒沙门氏菌中的诱变性。III. 9H-咔唑的甲基化衍生物
Mutat Res. 1997 Mar 17;389(2-3):247-60. doi: 10.1016/s1383-5718(96)00155-6.
5
Comparison of CoMFA models for Salmonella typhimurium TA98, TA100, TA98 + S9 and TA100 + S9 mutagenicity of nitroaromatics.鼠伤寒沙门氏菌TA98、TA100、TA98 + S9和TA100 + S9对硝基芳烃致突变性的CoMFA模型比较。
SAR QSAR Environ Res. 1998;9(3-4):187-215. doi: 10.1080/10629369808039156.
6
Mutagenic activities of selected nitrofluoranthene derivatives in Salmonella typhimurium strains TA98, TA98NR and TA98/1,8-DNP6.
Mutat Res. 1988 Oct;206(2):131-40. doi: 10.1016/0165-1218(88)90152-8.
7
Evaluation of the mutagenicity of nitration products derived from phenalenone (1H-phenalen-1-one).对菲烯酮（1H-菲-1-酮）衍生的硝化产物的致突变性评估。
Mutagenesis. 2008 Sep;23(5):359-66. doi: 10.1093/mutage/gen023. Epub 2008 May 13.
8
Structure-activity relationship of genotoxic polycyclic aromatic nitro compounds: further evidence for the importance of hydrophobicity and molecular orbital energies in genetic toxicity.遗传毒性多环芳族硝基化合物的构效关系：疏水性和分子轨道能量在遗传毒性中重要性的进一步证据
Environ Mol Mutagen. 1992;20(2):140-4. doi: 10.1002/em.2850200210.
9
A QSAR investigation of the role of hydrophobicity in regulating mutagenicity in the Ames test: 1. Mutagenicity of aromatic and heteroaromatic amines in Salmonella typhimurium TA98 and TA100.一项关于疏水性在艾姆斯试验中调节致突变性作用的定量构效关系研究：1. 芳香胺和杂芳香胺在鼠伤寒沙门氏菌TA98和TA100中的致突变性
Environ Mol Mutagen. 1992;19(1):37-52. doi: 10.1002/em.2850190107.
Zotero 插件