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[给新生大鼠和小鼠施用胍乙啶对交感神经节破坏的研究]

[Study of the destruction of the sympathetic ganglia by the administration of guanethidine to newborn rats and mice].

作者信息

Borisov M M, Mukhammedov A, Rodionov I M, Iarygin V N

出版信息

Ontogenez. 1977;8(3):311-3.

PMID:876612
Abstract

Following the injection of guanethidine (25 mg/kg) to rats from the first day of life during 2 weeks, over 70% of sympathic neurons in the stellate ganglion die. If the injections are carried out during 4 weeks, over 99% of neurons die. The injection of guanethidine to mice during 5 weeks did not result in the destruction of nerve elements in the ganglion, as compared with the control.

摘要

从出生第一天起,对大鼠连续两周注射胍乙啶(25毫克/千克),星状神经节中超过70%的交感神经元死亡。如果注射持续四周,超过99%的神经元死亡。与对照组相比,对小鼠连续五周注射胍乙啶并未导致神经节中神经元件的破坏。

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