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[给新生大鼠和小鼠施用胍乙啶对交感神经节破坏的研究]

[Study of the destruction of the sympathetic ganglia by the administration of guanethidine to newborn rats and mice].

作者信息

Borisov M M, Mukhammedov A, Rodionov I M, Iarygin V N

出版信息

Ontogenez. 1977;8(3):311-3.

PMID:876612
Abstract

Following the injection of guanethidine (25 mg/kg) to rats from the first day of life during 2 weeks, over 70% of sympathic neurons in the stellate ganglion die. If the injections are carried out during 4 weeks, over 99% of neurons die. The injection of guanethidine to mice during 5 weeks did not result in the destruction of nerve elements in the ganglion, as compared with the control.

摘要

从出生第一天起,对大鼠连续两周注射胍乙啶(25毫克/千克),星状神经节中超过70%的交感神经元死亡。如果注射持续四周,超过99%的神经元死亡。与对照组相比,对小鼠连续五周注射胍乙啶并未导致神经节中神经元件的破坏。

相似文献

1
[Study of the destruction of the sympathetic ganglia by the administration of guanethidine to newborn rats and mice].[给新生大鼠和小鼠施用胍乙啶对交感神经节破坏的研究]
Ontogenez. 1977;8(3):311-3.
2
[Effect of desympathization on thrombocyte aggregation capacity and the blood clotting potential of rats].[去交感神经对大鼠血小板聚集能力及血液凝固潜能的影响]
Biull Eksp Biol Med. 1980 Apr;89(4):395-7.
3
A new method of destroying adrenergic nerves in adult animals using guanethidine.一种使用胍乙啶破坏成年动物肾上腺素能神经的新方法。
Br J Pharmacol. 1971 Oct;43(2):295-301.
4
Changes of the rat superior cervical ganglion induced by guanethidine (histology and cholinesterase histochemistry).胍乙啶对大鼠颈上神经节的影响(组织学及胆碱酯酶组织化学)
Br J Pharmacol. 1968 Sep;34(1):211P-212P.
5
Effect of guanethidine on nerve cells and small intensely fluorescent cells in sympathetic ganglia of newborn and adult rats.胍乙啶对新生和成年大鼠交感神经节神经细胞及小而强荧光细胞的影响。
Acta Pharmacol Toxicol (Copenh). 1971;30(5):403-16. doi: 10.1111/j.1600-0773.1972.tb00672.x.
6
[Autoradiographic analysis of RNA synthesis by sympathetic neurocytes from a population depleted of nerve cells].[对来自神经细胞缺失群体的交感神经细胞RNA合成的放射自显影分析]
Biull Eksp Biol Med. 1977 Jun;83(6):746-8.
7
Ultrastructure of rat sympathetic ganglia following guanethidine.胍乙啶处理后大鼠交感神经节的超微结构
Acta Pharmacol Toxicol (Copenh). 1970;28(1):56.
8
[DNA concentration in the intracardiac neurons of intact and desympathized rats].
Biull Eksp Biol Med. 1974 Oct;78(10):104-7.
9
Histologic evaluation of the sympathectomy induced by guanethidine sulfate in neonatal rats.硫酸胍乙啶诱导新生大鼠交感神经切除术的组织学评估。
J Exp Zool. 1982 Sep 20;223(1):97-101. doi: 10.1002/jez.1402230117.
10
Excessively growing monoamine-containing nerves in mice during treatment with a nerve growth factor (NGF).在用神经生长因子(NGF)治疗期间,小鼠体内含单胺的神经过度生长。
Acta Physiol Scand. 1967 Jan-Feb;69(1):127-8. doi: 10.1111/j.1748-1716.1967.tb03501.x.

引用本文的文献

1
Effect of sympathectomy on platelet aggregation and blood coagulation in rats.交感神经切除术对大鼠血小板聚集和血液凝固的影响。
Experientia. 1980 Jul 15;36(7):849-50. doi: 10.1007/BF01978608.
2
Growth of sympathetic postganglionic axons after partial chemical destruction with guanethidine.用胍乙啶进行部分化学破坏后交感神经节后轴突的生长
Pflugers Arch. 1981 Dec;392(2):206-9. doi: 10.1007/BF00581273.