细小病毒B19感染与特发性血小板减少性紫癜

Parvovirus B19 infection and idiopathic thrombocytopenic purpura.

作者信息

van Elsacker-Niele A M, Weiland H T, Kroes A C, Kappers-Klunne M C

机构信息

Department of Virology, University Hospital, Leiden, The Netherlands.

出版信息

Ann Hematol. 1996 Mar;72(3):141-4. doi: 10.1007/s002770050152.

DOI:10.1007/s002770050152

PMID:8766256

Abstract

The potential association of human parvovirus B19 infection with idiopathic thrombocytopenic purpura (ITP) was studied. All 60 adult patients presenting with ITP at the University Hospital Rotterdam - Dijkzigt during a 12-year period (41 with acute ITP, 19 with chronic ITP) were included. Patient files were retrospectively analyzed. Stored serum samples were tested for parvovirus B19-specific IgG and IgM anti-bodies, and for parvovirus B19 DNA. In only one patient (1.7%) was evidence of recent B19 infection found. Parvovirus B19 is not a frequent cause of adult ITP and should be tested for only when there are other indications of possible parvovirus B19 involvement.

摘要

研究了人类细小病毒B19感染与特发性血小板减少性紫癜（ITP）之间的潜在关联。纳入了鹿特丹大学医学中心 - 迪克齐赫特分校在12年期间出现ITP的所有60例成年患者（41例急性ITP，19例慢性ITP）。对患者病历进行了回顾性分析。检测储存的血清样本中的细小病毒B19特异性IgG和IgM抗体以及细小病毒B19 DNA。仅在1例患者（1.7%）中发现了近期B19感染的证据。细小病毒B19不是成人ITP的常见病因，仅在有其他可能涉及细小病毒B19的指征时才应进行检测。