Kido S, Ito Y, Nishimura N, Kajita Y, Ozaki T
Department of Paediatrics, Showa Hospital, Aichi, Japan.
Acta Paediatr Jpn. 1998 Oct;40(5):486-8. doi: 10.1111/j.1442-200x.1998.tb01975.x.
We report two patients who presented with thrombocytopenic purpura (TP) associated with primary human parvovirus B19 (B19) infection. One patient also had transient liver dysfunction. In both cases, B19-DNA was detected in serum and bone marrow by polymerase chain reaction. Six months after the illness in patient 1 and 8 months after the illness in patient 2, B19-DNA disappeared from the serum. Serum immunoglobulin (Ig)G antibody to B19 remained positive in both cases, but B19 IgM antibody became negative 3 months after the onset in case 1 and 4 months after the onset in case 2. The mechanism of TP by B19 infection is unknown.
