García-Río F, Pino J M, Racionero M A, Gómez de Terreros Caro J, Prados C, Alvarez-Sala R, Villamor J
Service of Pneumology, La Paz Hospital, School of Medicine, Autonoma University, Madrid, Spain.
Allergol Immunopathol (Madr). 1996 May-Jun;24(3):125-8.
In spite of standardization of bronchial provocation tests, some methodological aspects yet are controversial. The role of saline solution inhalation is questionable. The measurement of mouth occlusion pressure 0.1 seconds after the onset of inspiration (P0.1) is a good means of detecting a response from bronchoprovocation tests.
We investigated the value of an initial challenge with nebulized saline in subjects undergoing methacholine challenge.
Eighty-four consecutive patients clinically suspected of bronchial asthma were studied. Bronchial methacholine challenge was performed by Chatham method. P0.1 before and three minutes after saline solution inhalation were determined by the method of Whitelaw.
There was no significant P0.1 change following the inhalation of the initial dose of nebulized saline either in those subjects who went on to produce a 20% decrement in FEV1 following a standardised methacholine challenge test, or in those subjects who proved to be non-reactors.
We shown that no modifications are present in respiratory center function when it is assessed by measurement of mouth occlusion pressure after saline solution inhalation in methacholine challenge. This may be another reason why saline solution challenge should be omitted from bronchoprovocation challenge.
尽管支气管激发试验已标准化，但一些方法学方面仍存在争议。吸入盐水的作用值得怀疑。吸气开始后0.1秒的口腔闭合压（P0.1）测量是检测支气管激发试验反应的一种好方法。
我们研究了雾化盐水初始激发对接受乙酰甲胆碱激发试验的受试者的价值。
对84例临床怀疑支气管哮喘的连续患者进行研究。采用查塔姆方法进行支气管乙酰甲胆碱激发试验。通过怀特洛方法测定吸入盐水前和吸入后三分钟的P0.1。
在标准化乙酰甲胆碱激发试验后FEV1下降20%的受试者，或被证明无反应的受试者中，吸入初始剂量雾化盐水后P0.1均无显著变化。
我们表明，在乙酰甲胆碱激发试验中，通过测量吸入盐水后的口腔闭合压来评估呼吸中枢功能时，呼吸中枢功能没有改变。这可能是支气管激发试验中应省略盐水激发试验的另一个原因。
