Reyes M G, Faraldi F, Chandran R, Verano A, Levi A C
Division of Pathology (Neuropathology), Hektoen Research Institute, Cook Conty Hospital, Chicago, IL 60612, USA.
Panminerva Med. 1996 Mar;38(1):8-14.
Histopathologic examination of the pars compacta of the substantia nigra of 17 patients with Alzheimer's disease showed Lewy bodies in six, neurofibrillary tangles in another six and only histologic changes that did not differ from age-matched controls in five patients. Four of the six patients with nigral Lewy bodies showed severe loss of neural cell bodies, reactive astrocytosis, gliosis and neuromelanin in macrophages and in the neuropile. By contrast, the loss of neuronal cell bodies in our patients without nigral Lewy bodies regardless of whether or not they also had nigral neurofibrillary tangles was no greater than what we observed in our age-matched controls. Quantitative cell counts confirmed our histopathologic estimates of neuronal loss. Our study and the findings of others show that the substantia nigra is often abnormal in Alzheimer's disease and that the abnormalities are rarely severe without nigral Lewy bodies.
对17例阿尔茨海默病患者黑质致密部进行组织病理学检查发现，6例有路易小体，6例有神经原纤维缠结，5例仅出现与年龄匹配的对照组无差异的组织学改变。6例有黑质路易小体的患者中，4例出现神经细胞体严重缺失、反应性星形细胞增生、胶质增生以及巨噬细胞和神经纤维网中的神经黑色素。相比之下，在我们的患者中，无论有无黑质神经原纤维缠结，没有黑质路易小体的患者神经细胞体的缺失并不比我们在年龄匹配的对照组中观察到的更严重。定量细胞计数证实了我们对神经元损失的组织病理学估计。我们的研究以及其他人的研究结果表明，在阿尔茨海默病中黑质常出现异常，且若无黑质路易小体，这些异常很少严重。
