Archer G T, Robson J E, Thompson A R
Pathology. 1977 Apr;9(2):137-53. doi: 10.3109/00313027709085252.
Phospholipid preparations from the nematode Ascaris suum or cysts of Echinococcus granulosus (hydatid cysts) induced an eosinophilia when injected into the peritoneal cavity of rats. Peritoneal eosinophilia persisted throughout 21 days of daily injections of Ascaris lipid and was accompanied by blood eosinophilia, mast cell granule lysis and mast cell hyperplasia. The active material consisted of lecithin and lecithin plasmalogen, and in aqueous suspension had a membrane-like appearance. Electron microscopy revealed that the phospholipid was ingested by all types of cells in the peritoneal cavity, including mast cells, and was rapidly broken down by eosinophils. Phagocytosis was found to be complement dependent. The lipid combined with properdin in human serum and stimulated complement breakdown via the alternative complement pathway.
将来自猪蛔虫的磷脂制剂或细粒棘球绦虫的囊肿（包虫囊肿）注射到大鼠腹腔内会引起嗜酸性粒细胞增多。在每天注射蛔虫脂质的21天内，腹腔嗜酸性粒细胞增多持续存在，并伴有血液嗜酸性粒细胞增多、肥大细胞颗粒溶解和肥大细胞增生。活性物质由卵磷脂和溶血卵磷脂组成，在水悬浮液中呈膜状外观。电子显微镜显示，磷脂被腹腔内的所有细胞类型摄取，包括肥大细胞，并被嗜酸性粒细胞迅速分解。发现吞噬作用依赖补体。该脂质与人血清中的备解素结合，并通过替代补体途径刺激补体分解。
