新型季铵氯化物的合成及其抗菌活性
Synthesis and antimicrobial activity of new quaternary ammonium chlorides.
作者信息
Brycki B, Skrzypczak A, Mirska I, Pernak J
机构信息
Department of Chemistry, Adam Mickiewicz University, Poznań, Poland.
出版信息
Arch Pharm (Weinheim). 1996 Jun;329(6):279-82. doi: 10.1002/ardp.19963290603.
PMID:8767111
Abstract
Decyldimethylamine reacts readily with chloromethylalkyl ethers of sulfides, chloromethylbenzyl ethers or sulfides and chloromethylcycloalkyl ethers to give quaternary ammonium chlorides in very good yields. All the chlorides studied showed antimicrobial activity. The relationship between the chemical structure and antimicrobial activity was analyzed by rough sets.
摘要
癸基二甲胺能与硫化物的氯甲基烷基醚、氯甲基苄基醚或硫化物以及氯甲基环烷基醚迅速反应，以很高的产率生成季铵氯化物。所有研究的氯化物均显示出抗菌活性。通过粗糙集分析了化学结构与抗菌活性之间的关系。
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