Flachenecker P, Hartung H P
Klinische Forschungsgruppe für Multiple Sklerose und Neuroimmunologie, Neurologische Klinik und Poliklinik, Julius-Maximilians-Universität, Würzburg.
Nervenarzt. 1996 Jun;67(6):435-43.
This review summarizes the natural history of multiple sclerosis (MS) in terms of disease type, survival, relapse rate and recovery as well as disability. The course of Ms is highly variable and individually difficult to predict. In epidemiological studies, the most common type of MS is the relapsing-remitting form. However, after 10-15 years of disease duration, 30-40% of patients will develop chronic progressive MS. Survival of all MS patients is only mildly affected, but markedly decreased in severely disabled patients mainly due to secondary complications. Suicide is more frequent in MS patients than in normals, especially within the first 5 years of the disease. The mean relapse rate ranges from approximately 0.5 to 0.8 relapses per year and decreases with time. Most patients will recover from relapses within 4 weeks. 50% of patients will require some form of walking aid within 15-18 years from onset. 20-40% of patients have ,,benign" MS, i.e. no or only mild disability after 10 years of MS.
本综述从疾病类型、生存率、复发率、恢复情况以及残疾程度等方面总结了多发性硬化症（MS）的自然史。MS的病程高度可变，个体情况难以预测。在流行病学研究中，最常见的MS类型是复发缓解型。然而，在病程10 - 15年后，30 - 40%的患者会发展为慢性进展型MS。所有MS患者的生存率仅受到轻微影响，但在严重残疾患者中显著降低，主要是由于继发并发症。MS患者自杀的频率高于正常人，尤其是在疾病的前5年内。平均复发率约为每年0.5至0.8次复发，且随时间降低。大多数患者会在4周内从复发中恢复。50%的患者在发病后15 - 18年内将需要某种形式的助行器。20 - 40%的患者患有“良性”MS，即在患MS 10年后无残疾或仅有轻微残疾。
