Willinger B, Beck-Mannagetta J, Hirschl A M, Makristathis A, Rotter M L
Abteilung für Klinische Mikrobiologie, Hygiene-Institut, Universität Wien, Osterreich.
Mycoses. 1996;39 Suppl 1:20-5. doi: 10.1111/j.1439-0507.1996.tb00498.x.
During the last years the appearance of radiopaque concrements in the maxillary sinus was reported. These could be identified as root-filling material for teeth of the upper jaw containing zinc oxide. This suggested that excess root-filling material containing zinc oxide in the maxillary sinus could favour the development of a local, non-invasive aspergillosis. Therefore, we tested Aspergillus fumigatus, A. flavus, A. terreus, A. nidulans and A. niveus for the influence of zinc oxide. Cza-pek-Dox agar was inoculated with the six different Aspergillus strains. Circular cavities stamped into the agar's center of each plate were filled with aliquots of the dilutions of a geometric series of zinc oxide dissolved in 0,1n H2SO4. All plates were then incubated for seven days at 37 degrees C. Readings were taken on the 3rd, the 5th and the 7th day. It became obvious that solved zinc oxide promotes the growth of all the tested Aspergillus species. This influence diminished with decreasing concentration. This effect could be observed on all days of measurement. Only A. niger showed an attenuated dependence, probably due to the a priori high growth rate of this species on Czapek-Dox agar. It is concluded that overfilling of maxillary teeth with a zinc oxide containing root filling material favours the development of local aspergillosis.
在过去几年中，有上颌窦内出现不透射线凝结物的报道。这些凝结物可被鉴定为含有氧化锌的上颌牙齿的根管充填材料。这表明上颌窦内过量的含氧化锌根管充填材料可能有利于局部非侵袭性曲霉病的发展。因此，我们测试了烟曲霉、黄曲霉、土曲霉、构巢曲霉和雪白曲霉对氧化锌的反应。用六种不同的曲霉菌株接种察氏培养基。在每个平板培养基中心冲压出的圆形空洞中，加入溶解于0.1N硫酸中的几何级数氧化锌稀释液的等分试样。然后将所有平板在37℃下孵育7天。在第3天、第5天和第7天进行读数。结果明显显示，溶解的氧化锌促进了所有受试曲霉菌种的生长。这种影响随着浓度降低而减弱。在所有测量日均可观察到这种效应。只有黑曲霉表现出较弱的依赖性，这可能是由于该菌种在察氏培养基上原本就具有较高的生长速率。结论是，用含氧化锌的根管充填材料对上颌牙齿进行超充有利于局部曲霉病的发展。
