Paul K D, Leupold W, Blaschke-Hellmessen R, Ulbrich K, Peter-Kern M, Neumeister V
Klinik und Poliklinik für Kinderheilkunde, Universitätsklinikum Carl Gustav Carus, Technischen Universität Dresden, BR Deutschland.
Mycoses. 1996;39 Suppl 1:55-8. doi: 10.1111/j.1439-0507.1996.tb00506.x.
Intermittent or long term treatment with antibiotics, progredient destruction of the lungs as well as dystrophy of individuals are predisposing factors for the colonization of the respiratory tract with Aspergillus fumigatus in CF patients. Allergic bronchopulmonary aspergillosis (ABPA) is a significant problem in CF patients. It has been reported with an incidence of 10%. The diagnosis of ABPA in patients with CF is difficult since it is common for both diseases to have several of the same clinical and laboratory features. Prednisolone with an initial dose of between 0,5-1,0 mg/kg/day remains the treatment of choice for ABPA. The doses reduction and the duration of the treatment depend on clinical findings and on serum IgE levels.
抗生素的间歇性或长期治疗、肺部的进行性破坏以及个体营养不良是囊性纤维化（CF）患者呼吸道被烟曲霉定植的易感因素。变应性支气管肺曲霉病（ABPA）在CF患者中是一个重要问题。据报道其发病率为10%。CF患者中ABPA的诊断很困难，因为这两种疾病通常有一些相同的临床和实验室特征。初始剂量为0.5 - 1.0毫克/千克/天的泼尼松龙仍然是ABPA的首选治疗药物。剂量的减少和治疗持续时间取决于临床发现和血清IgE水平。
