Kazis A, Kimiskidis V, Georgiadis G, Kapinas K
Department of Neurology, Aristotle University of Thessaloniki, G-Papanikolaou Hospital, Greece.
Neurophysiol Clin. 1996;26(2):75-84. doi: 10.1016/0987-7053(96)83148-0.
Fourteen patients with myotonic dystrophy (MyD) were studied with means of an auditory "oddball" event-related potential (ERP) paradigm. The results were compared with data from 53 controls. The early components (N1, P2) of the ERP were not affected, whereas later components (N2, P3), which are thought to reflect cognitive processes, were abnormal in eight patients who were the oldest in the sample. Magnetic resonance imaging (MRI) was performed in twelve patients and revealed, in five of them, multiple focal white matter lesions. These findings, however, could not be associated with neurophysiological abnormalities. It is concluded, that cognitive ERP, particularly N2 and P3 components, are abnormal in some patients suffering from MyD. Possible etiologies of the electrophysiological abnormalities are discussed.
采用听觉“oddball”事件相关电位（ERP）范式对14例强直性肌营养不良（MyD）患者进行了研究。将结果与53名对照者的数据进行了比较。ERP的早期成分（N1、P2）未受影响，而被认为反映认知过程的后期成分（N2、P3）在样本中年龄最大的8例患者中出现异常。对12例患者进行了磁共振成像（MRI）检查，其中5例显示有多个局灶性白质病变。然而，这些发现与神经生理异常并无关联。得出结论，在一些MyD患者中，认知ERP，尤其是N2和P3成分是异常的。文中讨论了电生理异常可能的病因。
