Careddu P, Mirra N, D'Angelo E, Carnelli V
Clinica Pediatrica I, Università degli Studi di Milano, Italia.
Pediatr Med Chir. 1996 Mar-Apr;18(2):155-60.
In twenty eight patients with iron deficiency the efficacy of iron-acetil-transferrin treatment (2-3 mg/kg/die) has been evaluated from the changes of the following variables: RBC and reticulocyte count, Hb concentration, MCV, MCH, serum ferritin, serum iron, TIBC, and ZnPP. These variables were assessed before and after three months of treatment in all patients, and after three months from the end of the treatment in thirteen patients. At the end of the treatment there was a significant increase of RBC count, Hb concentration, MCV, MCH, serum ferritin, serum iron, and TIBC, a significant decrease of ZnPP, while reticulocyte count remained essentially unchanged. After three months from the end of the treatment only serum ferritin and ZnPP underwent an additional significant increase and decrease, respectively. In twenty-six patients serum ferritin values returned to normal. The changes of RBC and reticulocyte count, Hb concentration, MCV, serum iron, and TIBC were larger the lower the initial values, suggesting that the efficacy of the treatment is greater the more serious the iron deficiency.
在28例缺铁患者中，通过观察以下指标的变化评估了乙酰转铁蛋白铁治疗（2 - 3mg/kg/天）的疗效：红细胞计数、网织红细胞计数、血红蛋白浓度、平均红细胞体积（MCV）、平均红细胞血红蛋白含量（MCH）、血清铁蛋白、血清铁、总铁结合力（TIBC）和锌原卟啉（ZnPP）。对所有患者在治疗三个月前后以及13例患者在治疗结束三个月后评估了这些指标。治疗结束时，红细胞计数、血红蛋白浓度、MCV、MCH、血清铁蛋白、血清铁和TIBC显著升高，ZnPP显著降低，而网织红细胞计数基本保持不变。治疗结束三个月后，仅血清铁蛋白和ZnPP分别进一步显著升高和降低。26例患者的血清铁蛋白值恢复正常。红细胞计数、网织红细胞计数、血红蛋白浓度、MCV、血清铁和TIBC的初始值越低，其变化越大，表明缺铁越严重，治疗效果越好。
