Visconti W, Fontana P, Buonocore P, Grillo N, Seno S
Centro di Chirurgia Vascolare, Reparto di Chirurgia Generale, Ospedale, G.B. Giustinian, Venezia.
Minerva Cardioangiol. 1996 Jan-Feb;44(1-2):19-27.
From 1989 to 1992 83 patients suffering from peripheral vascular disease without medical or surgical possibilities, were treated by spinal cord stimulation (SCS). We studied claudicatio intermittens, rest pain and ischemic lesion behaviour in all the patients. We also studied microcirculation behaviour of 21 patients, by oxygen transcutaneous tension (vasodilatation index VI = TcPO2 42 degrees C: TcPO2 45 degrees C) and laser Doppler flowmetry (resting flow RF, standing flow SF, venoarteriolar reflex VAR = RF - SF, flow temperature increase FTI = F 40 degrees C 15'-RF). The clinical follow-up at 2 years showed an improvement of walking distance in 85.7% of 7 controls, a complete rest pain control in 82.35% of 17 controls, an improvement and healing of ischemic lesions respectively in 27.07% and 53.86% of 18 controls. In arteriosclerotic arteriopathy with or without diabetes but without neuropathy VI increased and FTI decreased, after SCS, showing a sympathetic tone decrease. In arteriosclerotic arteriopathy with diabetic neuropathy V.I. decreased and FTI increased, after SCS, showing a sympathetic tone reappearance. VAR improved or reappeared, in arteriosclerotic arteriopathy with or without diabetes, showing improvement of tissue perfusion as regards a better efficiency of "paramicrovessels" and "microvascular unit". We believe that SCS, as regards favourable clinical results represents a useful and effective treatment in peripheral vascular disease treatment.
1989年至1992年期间,83例患有周围血管疾病且无药物或手术治疗可能性的患者接受了脊髓刺激(SCS)治疗。我们研究了所有患者的间歇性跛行、静息痛和缺血性病变情况。我们还通过经皮氧分压(血管扩张指数VI = 42℃时的经皮氧分压:45℃时的经皮氧分压)和激光多普勒血流仪(静息血流RF、站立血流SF、静脉动脉反射VAR = RF - SF、血流温度升高FTI = 40℃ 15分钟后的血流 - RF)研究了21例患者的微循环情况。2年的临床随访显示,7例对照组中有85.7%的患者步行距离有所改善,17例对照组中有82.35%的患者静息痛得到完全控制,18例对照组中有27.07%和53.86%的患者缺血性病变分别得到改善和愈合。在有或无糖尿病但无神经病变的动脉硬化性动脉病中,SCS后VI升高而FTI降低,表明交感神经张力降低。在伴有糖尿病神经病变的动脉硬化性动脉病中,SCS后VI降低而FTI升高,表明交感神经张力再现。在有或无糖尿病的动脉硬化性动脉病中,VAR改善或再现,表明“微动脉旁血管”和“微血管单位”效率提高,组织灌注得到改善。我们认为,就良好的临床效果而言,SCS在外周血管疾病治疗中是一种有用且有效的治疗方法。