Sangari F J, Agüero J
Departamento de Biología Molecular, Facultad de Medicina, Universidad de Cantabria, Santander, España.
Microbiologia. 1996 Jun;12(2):207-18.
Microorganisms belonging to the genus Brucella can infect humans and many species of animals. Virulence of the brucellae is thought to be essentially due to their capacity to survive and replicate within the phagocytic cells. However, many gaps remain in our understanding of this ability of brucellae to elude the bactericidal effects of host phagocytes, and basic questions remain unanswered. Identification of Brucella gene products which are related to intracellular survival, as well as those which contribute to the induction of protective immunity, is critical to elucidate the molecular mechanisms of the pathogenesis of the organism. The present article summarizes the current status of the research on gene products and other structural or metabolic factors associated with virulence of the brucellae.
布鲁氏菌属的微生物可感染人类和许多动物物种。布鲁氏菌的毒力被认为主要归因于它们在吞噬细胞内存活和复制的能力。然而，我们对布鲁氏菌逃避宿主吞噬细胞杀菌作用的这种能力的理解仍存在许多空白，一些基本问题也尚未得到解答。鉴定与细胞内存活相关的布鲁氏菌基因产物以及那些有助于诱导保护性免疫的基因产物，对于阐明该生物体发病机制的分子机制至关重要。本文总结了与布鲁氏菌毒力相关的基因产物及其他结构或代谢因子的研究现状。
