Ludwig A
Lehrstuhl für Mikrobiologie, Theodor-Boveri-Institut für Biowissenschaften (Biozentrum), Universität Würzburg, Germany.
Microbiologia. 1996 Jun;12(2):281-96.
Many Gram-negative bacterial pathogens synthesize cytolytic toxins as virulence factors. Most of these toxins generate pores in eukaryotic cell membranes, but there are apparently several different mechanisms of pore formation. Cytolysins of Gram-negative bacteria are usually synthesized as precursor proteins which are converted to the active toxins by modification or proteolytic processing. Such a requirement for activation is not common for cytolysins produced by Gram-positive bacteria. The extracellular secretion of cytolytic toxins from Gram-negative bacteria depends on specific transport systems.
许多革兰氏阴性细菌病原体合成细胞溶解毒素作为毒力因子。这些毒素中的大多数会在真核细胞膜上形成孔道，但显然存在几种不同的孔道形成机制。革兰氏阴性细菌的细胞溶素通常以前体蛋白的形式合成，通过修饰或蛋白水解加工转化为活性毒素。革兰氏阳性细菌产生的细胞溶素通常不需要这样的激活过程。革兰氏阴性细菌细胞溶解毒素的胞外分泌依赖于特定的转运系统。
