Perret J L, Moussavou-Kombila J B, Delaporte E, Coniquet S, Nguemby-Mbina C, Normand P
Service de Médecine A, Centre Hospitalier de Libreville, Gabon.
Med Trop (Mars). 1996;56(1):66-8.
Association of human T-lymphotropic virus type-1 (HTLV-1) with T-cell malignancy is well-known but its relationship with mycosis fungoides is controversial. Typical mycosis fungoides was diagnosed at tumor stage in a 58-year-old Gabonese woman also infected with HTLV-1. Infection with lymphoma of the skin is uncommon in Africa but it is probably underestimated. Association of mycosis fungoides with retrovirus infection could be coincidental since there is a high prevalence of HTLV-1 in Gabon and the only currently recognized association is T-cell leukemia/lymphoma. However recent data indicate the presence of similar retrovirus particles and a common tax gene in the monocytes of most patients presenting mycosis fungoides.
人类嗜T淋巴细胞病毒1型（HTLV-1）与T细胞恶性肿瘤的关联已为人熟知，但其与蕈样肉芽肿的关系仍存在争议。一名58岁同时感染HTLV-1的加蓬女性在肿瘤期被诊断为典型的蕈样肉芽肿。皮肤淋巴瘤感染在非洲并不常见，但可能被低估了。蕈样肉芽肿与逆转录病毒感染的关联可能是巧合，因为加蓬HTLV-1的患病率很高，目前唯一公认的关联是T细胞白血病/淋巴瘤。然而，最近的数据表明，大多数患有蕈样肉芽肿的患者的单核细胞中存在类似的逆转录病毒颗粒和共同的tax基因。
