[Monoamine metabolism in the rat striatum during actions on the nucleus accumbens].

In vivo microdialysis in conscious rats combined with HPLC-EC analysis was used to monitor extracellular levels of 3, 4-dihydroxyphenilacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the dorsal striatum (STR) during infusions of procain and apomorphine into the nucleus accumbens (N.acc). It was shown that apomorphine infused into the N.acc (2 x 10(-5) M) caused a decrease in striatal extracellular levels of DOPAC, HVA, and 5-HIAA. Infusions of procain into the N.acc (10(-5) M) produced an increase in extracellular DOPAC, and HVA in the STR. Data indicated that the N.acc exerts an inhibitory influence on the metabolism of dopamine in the STR, the influence being under control of dopaminergic system of the N.acc.