Schwab U M, Harten P, Zeuner R A, Külper M, Euler H H
2. Medizinische Universitäts-Klinik, Kiel.
Z Rheumatol. 1996 May-Jun;55(3):174-9.
Nine patients with SLE-associated neutropenia and infections received 48 Mio U G-CSF per day s.c. for 2-17 days as an adjunct to antibiotic treatment. Granulopoiesis was normal or hyperplastic in all cases. The mean granulocyte count increased within 2 days from 1.4 per nl to 11.4 per nl. Side-effects were exacerbating CNS symptoms in two patients and a case of leukocytoclastic vasculitis. G-CSF induced constantly a rapid and distinct increase of neutrophil granulocytes in lupus-associated neutropenia patients with normo- or hyperplastic granulopoiesis.
9例系统性红斑狼疮相关中性粒细胞减少症及感染患者，在接受抗生素治疗的同时，皮下注射粒细胞集落刺激因子（G-CSF），剂量为每日4800万单位，疗程2 - 17天。所有病例的粒细胞生成均正常或增生。粒细胞计数平均在2天内从每微升1.4升至每微升11.4。副作用包括2例患者中枢神经系统症状加重以及1例白细胞破碎性血管炎。G-CSF持续诱导狼疮相关中性粒细胞减少症且粒细胞生成正常或增生患者的中性粒细胞迅速且显著增加。
