Janoutovă J, Măra M, Likovsky Z
Institute of Histology and Embryology, 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.
Folia Microbiol (Praha). 1995;40(6):652-4. doi: 10.1007/BF02818524.
Factor Ei isolated from Listeria monocytogenes caused in rabbits 1 d after intravenous administration activation of peripheral blood lymphocytes in terms of rRNA biosynthesis. Increase of the number of these active lymphocytes was observed not only in peripheral blood, but also in spleen, lung, kidney, and liver. when the number of lymphocytes was related to the amount of the organ tissue cells, the increment appeared significant only in the liver where the number of active lymphocytes exceeded the control value by one order of magnitude. Based upon this observation we concluded that the accumulation of Listeria factor Ei activated lymphocytes occurred in liver. This characteristic is considered an additional immunomodulative property of Listeria factor Ei similar to the Escherichia coli lipopolysaccharide.
从单核细胞增生李斯特菌中分离出的E1因子，在静脉注射给兔子1天后，就rRNA生物合成而言，可引起外周血淋巴细胞活化。不仅在外周血中观察到这些活性淋巴细胞数量增加，在脾脏、肺、肾脏和肝脏中也观察到了。当淋巴细胞数量与器官组织细胞数量相关时，仅在肝脏中增量显著，其中活性淋巴细胞数量超过对照值一个数量级。基于这一观察结果，我们得出结论，李斯特菌E1因子激活的淋巴细胞在肝脏中积累。这一特性被认为是李斯特菌E1因子类似于大肠杆菌脂多糖的另一种免疫调节特性。
