Schell R, Musher D, Jacobson K, Schwethelm P
J Immunol. 1975 Feb;114(2 Pt 1):550-3.
Syphilitic rabbits have previously been shown to resist challenge with Listeria monocytogenes. Thirty days after rabbits were infected with Treponema pallidum, transfer of 4 to 6 times 10-8 viable spleen cells along with T. pallidum conferred resistance to Listeria on normal recipients. Treatment of the spleen cells with anti-thymus serum and complement inhibited or abolished their ability to transfer resistance to Listeria. These results support the hypothesis that the ability of syphilitic rabbits to suppress the growth of Listeria reflects stimulation of cell-mediated immunity during active infection with T. pallidum.
先前已证明感染梅毒的兔子能抵抗单核细胞增生李斯特菌的攻击。兔子感染梅毒螺旋体30天后，将4至6×10⁻⁸个活的脾细胞与梅毒螺旋体一起转移给正常受体，可使其对李斯特菌产生抗性。用抗胸腺血清和补体处理脾细胞会抑制或消除它们转移对李斯特菌抗性的能力。这些结果支持了这样的假说，即感染梅毒的兔子抑制李斯特菌生长的能力反映了在梅毒螺旋体活跃感染期间细胞介导免疫的刺激。
