Litzman J, Pejcochová J, Lokaj J
Ustav klinické imunologie LF MU, FN U sv. Anny.
Vnitr Lek. 1996 May;42(5):324-6.
The presence of hepatitis C virus (HCV) was investigated in 20 agammaglobulinemic patients using polymerase chain reaction (PCR) and by specific anti-HCV antibodies detection. Fourteen patients suffered from common variable immunodeficiency (CVID), 5 patients from X-linked agammaglobulinemia and one from specific antibody-formation deficiency. All patients were treated by the replacement immunoglobulin therapy (6-30 years), in 19 of them also intravenous immunoglobulin was used. Although 2 patients suffered from chronic hepatic disease (chronic active hepatitis and granulomatous hepatitis of unknown origin), in none of the investigated patients any laboratory marker of HCV infection was proved. Although no HCV infection was observed in our group of patients, PCR for HCV-RNA should be performed in all patients previously treated by the intravenous immunoglobulin.
采用聚合酶链反应（PCR）和特异性抗丙型肝炎病毒（HCV）抗体检测法，对20例无丙种球蛋白血症患者进行了HCV检测。14例患者患有常见可变免疫缺陷（CVID），5例患有X连锁无丙种球蛋白血症，1例患有特异性抗体形成缺陷。所有患者均接受替代免疫球蛋白治疗（6至30年），其中19例还使用了静脉注射免疫球蛋白。尽管2例患者患有慢性肝病（慢性活动性肝炎和病因不明的肉芽肿性肝炎），但在所有被调查患者中均未证实有任何HCV感染的实验室指标。尽管在我们的患者组中未观察到HCV感染，但对于所有曾接受静脉注射免疫球蛋白治疗的患者，均应进行HCV-RNA的PCR检测。
