Wieraszko A
CSI/IBR Center for Developmental Neuroscience and Developmental Disabilities, College of Staten Island/City University of New York, NY 10314, USA.
Acta Neurobiol Exp (Wars). 1996;56(2):637-48. doi: 10.55782/ane-1996-1168.
Growing evidence indicates that ATP may play a very important role in Long-Term Potentiation (LTP), a neurophysiological process that has been implicated in memory formation. LTP is an enhancement of synaptic strength induced by a specific pattern of high frequency stimulation, or by application of exogenous ATP. In the hippocampus LTP-inducing stimulation is accompanied by a massive, Ca(2+)-dependent release of ATP from presynaptic terminals. Released extracellular ATP may either interact with numerous types of ATP receptors present on the neuronal surface, or serve as a substrate for ecto-protein phosphorylation. The results of combined electrophysiological and biochemical experiments indicate that participation of extracellular ATP in the ecto-protein phosphorylation process is most likely involved in the permanent amplification of the synaptic response in the hippocampus.
越来越多的证据表明，三磷酸腺苷（ATP）可能在长时程增强（LTP）中发挥非常重要的作用，LTP是一种与记忆形成有关的神经生理过程。LTP是由特定模式的高频刺激或通过施加外源性ATP诱导的突触强度增强。在海马体中，诱导LTP的刺激伴随着大量依赖钙离子的ATP从突触前末端释放。释放到细胞外的ATP可能与存在于神经元表面的多种类型的ATP受体相互作用，或作为胞外蛋白磷酸化的底物。电生理和生化实验相结合的结果表明，细胞外ATP参与胞外蛋白磷酸化过程很可能与海马体中突触反应的永久性增强有关。
