Giedd J N, Rapoport J L, Leonard H L, Richter D, Swedo S E
Child Psychiatry Branch, NIMH, Bethesda, MD 20892-1600, USA.
J Am Acad Child Adolesc Psychiatry. 1996 Jul;35(7):913-5. doi: 10.1097/00004583-199607000-00017.
Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAs) may arise when antibodies directed against invading bacteria cross-react with basal ganglia structures, resulting in exacerbations of obsessive-compulsive disorder (OCD) or tic disorders. This is a report of severe worsening of obsessive-compulsive symptoms in an adolescent boy following infection with group A beta-hemolytic streptococci for whom serial magnetic resonance imaging scans of the brain were acquired to assess the relationship between basal ganglia size, symptom severity, and treatment with plasmapheresis. These data provide further support for basal ganglia-mediated dysfunction in OCD and the potential for immunological treatments in PANDAs patients.
与链球菌感染相关的儿童自身免疫性神经精神障碍（PANDAs）可能在针对入侵细菌的抗体与基底神经节结构发生交叉反应时出现，导致强迫症（OCD）或抽动障碍加重。本文报告了一名青少年男性在感染A组β溶血性链球菌后强迫症症状严重恶化的病例，对其进行了一系列脑部磁共振成像扫描，以评估基底神经节大小、症状严重程度与血浆置换治疗之间的关系。这些数据进一步支持了基底神经节介导的强迫症功能障碍以及PANDAs患者免疫治疗的潜力。
