Jira P E, Semmekrot B A, Vree T B, Monnens L A
Afd. Kindergeneeskunde, Academisch Ziekenhuis, Nijmegen.
Ned Tijdschr Geneeskd. 1996 Aug 3;140(31):1608-11.
Three infants aged 1, 3 and 9 months with severe theophylline intoxication are reported. Maximum serum theophylline concentrations were 65, 44 and 156 mg/l, respectively. Vomiting, agitation and tachycardia are the classical features. Seizures and cardiac arrhythmias suggest severe intoxication. The third patient underwent immediate peritoneal dialysis. All patients survived and recovered without sequelae. Haemoperfusion is considered to be the definite treatment for severe forms of theophylline intoxication.
报告了3例分别为1个月、3个月和9个月大的严重茶碱中毒婴儿。血清茶碱最高浓度分别为65、44和156mg/l。呕吐、烦躁和心动过速是典型症状。癫痫发作和心律失常提示严重中毒。第三名患者立即接受了腹膜透析。所有患者均存活且康复，无后遗症。血液灌流被认为是治疗严重茶碱中毒的明确方法。
