Barker L F, Shulman N R, Murray R, Hirschman R J, Ratner F, Diefenbach W C, Geller H M
JAMA. 1996 Sep 11;276(10):841-4.
There is evidence that transmission of serum hepatitis is associated with transmission of virus-like particles, approximately, 20 millimicron in diameter, containing the Australia or serum hepatitis (SH) antigen, which is currently referred to as the hepatitis associated antigen (HAA). Virus-like particles containing HAA were in the following materials, inoculation of which produced serum hepatitis: (1) a pool of human plasma, (2) serum obtained during the acute phase of hepatitis from a recipient of the plasma pool, (3) a preparation of human thrombin, and (4) serum from a proved hepatitis carrier. The HAA appeared in the serum samples of 61 individuals inoculated with these materials; serum hepatitis developed in 38 of them. Inoculation of dilutions of the plasma pool showed that serum hepatitis can be transmitted by materials containing HAA in amounts too low to be detected by current techniques.
有证据表明，血清性肝炎的传播与直径约为20毫微米、含有澳大利亚或血清性肝炎（SH）抗原（目前称为肝炎相关抗原（HAA））的病毒样颗粒的传播有关。含有HAA的病毒样颗粒存在于以下物质中，接种这些物质会引发血清性肝炎：（1）一批人血浆；（2）从接受该批血浆者在肝炎急性期获得的血清；（3）一种人凝血酶制剂；（4）一名已证实的肝炎携带者的血清。61名接种了这些物质的个体的血清样本中出现了HAA；其中38人患上了血清性肝炎。对接种该批血浆稀释液的研究表明，血清性肝炎可通过含有低至当前技术无法检测到的量的HAA的物质传播。
