Tanaka E, Mishima M, Kawakami K, Sakai N, Sugiura N, Taniguchi T, Ohi M, Itoh H, Kuno K
Department of Clinical Physiology, Chest Disease Research Institute, Kyoto University, Japan.
Ann Nucl Med. 1995 Nov;9(4):209-13. doi: 10.1007/BF03168403.
N-isopropyl-p-[123I]iodoamphetamine (123I-IMP) was injected intravenously into primary non small cell lung carcinoma patients (n = 17). The average pixel count ratios of the cancerous area to the whole lung was measured in the initial and delayed images. In the initial image, this ratio was less than 1.0 for the entire group of patients, and was thought to reflect decreased blood flow in the cancerous tissues. The rate of counts within a ROI in the delayed image to counts in the same ROI in the initial image was also calculated and called the remain rate. The remain rate (delayed count/initial count) was significantly higher in the cancerous area than in the whole lung (0.65 +/- 0.30, median 0.62, 0.38 +/- 0.05, median 0.38, p < 0.01). This observation was thought to be due to a relative decrease in the blood flow and the accumulation of IMP, which forms pools within the alveolar spaces of the cancerous areas. The image prepared with the remain rate revealed a hot image in the cancerous regions, even when this was not apparent in the delayed image. The remain rate image may therefore be useful in the identification of cancerous areas in lung tissue if it is used in comparison with the initial image.
将N-异丙基-p-[123I]碘安非他明（123I-IMP）静脉注射到原发性非小细胞肺癌患者（n = 17）体内。在初始图像和延迟图像中测量癌灶区域与全肺的平均像素计数比值。在初始图像中，整个患者组的该比值均小于1.0，被认为反映了癌组织血流减少。还计算了延迟图像中感兴趣区域（ROI）内的计数与初始图像中同一ROI内计数的比率，称为残留率。癌灶区域的残留率（延迟计数/初始计数）显著高于全肺（0.65±0.30，中位数0.62；0.38±0.05，中位数0.38，p<0.01）。这一观察结果被认为是由于血流相对减少以及IMP的蓄积，IMP在癌灶区域的肺泡腔内形成池。用残留率制备的图像显示癌灶区域为热图像，即使在延迟图像中不明显时也是如此。因此，如果将残留率图像与初始图像对比使用，可能有助于识别肺组织中的癌灶区域。
