以色列犹太发作性睡病患者的HLA II类分析。

HLA class II analysis in Jewish Israeli narcoleptic patients.

作者信息

Kwon O J, Peled N, Miller K, Pillar G, Peled R, Lavie P, Brautbar C, Amar A

机构信息

Tissue Typing Unit, Hebrew University-Hadassah Medical Organization, Jerusalem, Israel.

出版信息

Hum Immunol. 1995 Dec;44(4):199-202. doi: 10.1016/0198-8859(95)00106-9.

DOI:10.1016/0198-8859(95)00106-9

PMID:8770632

Abstract

HLA class II was investigated in eight Jewish narcoleptic patients, representing the total of such patients known in Israel at present, and in three patients suffering from sleep disturbances other than narcolepsy. All (11 out of 11) patients carried the serologic specificities DR2, DQ6 (DQ1). At the DNA level, all narcoleptics were found to be DRB11501, DQA10102, DQB10602 which indicates that the susceptibility gene may be located within the HLA class II region, DR, and/or DQ. As for the nonnarcoleptic patients with idiopathic hypersomnia, they carried different alleles of DR2 and DQ6, namely DRB11502, DQA10103, DQB10601. This study confirms that the incidence of narcolepsy in Israel is extremely low and that HLA class II genes or a gene(s) tightly linked to them are involved in the disease.

摘要

对8名犹太发作性睡病患者进行了HLA II类研究，这些患者代表了以色列目前已知的所有此类患者，还对3名患有发作性睡病以外睡眠障碍的患者进行了研究。所有患者（11名患者中的11名）均具有血清学特异性DR2、DQ6（DQ1）。在DNA水平上，所有发作性睡病患者均被发现为DRB11501、DQA10102、DQB10602，这表明易感基因可能位于HLA II类区域、DR和/或DQ内。至于患有特发性嗜睡症的非发作性睡病患者，他们携带不同的DR2和DQ6等位基因，即DRB11502、DQA10103、DQB10601。这项研究证实，以色列发作性睡病的发病率极低，且HLA II类基因或与之紧密连锁的一个或多个基因与该病有关。