Raftopoulos C, Dethy S, Laute M A, Goldman S, Naini A B, Przedborski S, Hildebrand J
Service de Neurochirurgie, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
Mov Disord. 1996 Jan;11(1):59-62. doi: 10.1002/mds.870110111.
Concentrations of major catabolites of dopamine were followed in the ventricular cerebrospinal fluid (CSF) in five patients undergoing intracranial pressure monitoring for chronic hydrocephalus. Determinations were made every 2 h following the administration of carbidopa/levodopa 25/250 mg (one Sinemet capsule) given 8 h apart. The rise of homovanillic acid (HVA) concentrations was slow and progressive, reaching the level of statistical significance (p < or = 0.01) only 8 h after the second administration of Sinemet. The rise in 3,4-dihydroxyphenylacetic acid (DOPAC) was faster than the rise in HVA, with the peak value detected 4 h after the first administration of Sinemet. These data are interpreted as a confirmation, in humans, of a slow pool of exogenous levodopa, previously demonstrated in animal studies.
对5名因慢性脑积水接受颅内压监测的患者，测定其脑室脑脊液（CSF）中多巴胺主要分解代谢产物的浓度。每隔8小时给予25/250毫克卡比多巴/左旋多巴（一粒息宁胶囊），给药后每2小时进行一次测定。高香草酸（HVA）浓度升高缓慢且呈进行性，仅在第二次给予息宁8小时后才达到统计学显著水平（p≤0.01）。3,4-二羟基苯乙酸（DOPAC）的升高比HVA快，在首次给予息宁4小时后检测到峰值。这些数据被解释为在人体中证实了先前在动物研究中证明的外源性左旋多巴的缓慢蓄积。
