Takubo K, Nixon J M, Jass J R
Division of Clinical Pathology, Tokyo Metropolitan Geriatric Hospital, Japan.
Pathology. 1995 Oct;27(4):315-7. doi: 10.1080/00313029500169213.
The frequency of ducts of esophageal glands proper and Paneth cells was studied in endoscopic biopsy specimens obtained from 49 patients diagnosed as having Barrett's esophagus. Esophageal gland ducts were found in 5 (10%) of the subjects. Paneth cells were observed in 15 (31%) of the 49 patients, being located mainly among mucous cells of intestinalized crypts although a few were also noted in the surface epithelium. Since the presence of esophageal gland ducts in the columnar epithelium-lined mucosa is a pathognomonic feature of Barrett's esophagus, 10% of the patients reviewed were considered to have an unequivocal diagnosis of Barrett's esophagus. Barrett's mucosa showed histological features similar to incomplete-type intestinal metaplasia of gastric mucosa, except for the presence of Paneth cells.
对49例诊断为巴雷特食管的患者所取的内镜活检标本中食管固有腺导管和潘氏细胞的出现频率进行了研究。在5名（10%）受试者中发现了食管腺导管。在49例患者中的15例（31%）观察到了潘氏细胞，主要位于肠化生隐窝的黏液细胞之间，不过在表面上皮中也发现了少数潘氏细胞。由于在柱状上皮衬里的黏膜中存在食管腺导管是巴雷特食管的一个特征性表现，因此所复查的患者中有10%被认为明确诊断为巴雷特食管。除了存在潘氏细胞外，巴雷特黏膜显示出与胃黏膜不完全型肠化生相似的组织学特征。
