Sofuoğlu S, Doğan P, Köse K, Eşel E, Baştũrk M, Oğuz H, Gönül A S
Department of Psychiatry, Erciyes University Research Hospital, Kayseri, Turkey.
Psychiatry Res. 1995 Nov 29;59(1-2):165-70. doi: 10.1016/0165-1781(95)02631-2.
The activity of monoamine oxidase (MAO) and dopamine-beta-hydroxylase (DBH), enzymes involved in monoamine metabolism, were studied in 29 bipolar patients (mean age = 33.12 years, SD = 7.27) who were treated with lithium carbonate and in 20 healthy volunteers (mean age = 30.05 years, SD = 6.04). Platelet MAO activity was higher after lithium withdrawal, whereas plasma DBH activity was lower in remitted euthymic bipolar patients compared with normal volunteers. During lithium treatment, platelet MAO activity decreased and plasma DBH activity increased compared with the lithium-withdrawal values. It was also observed that the activities of these enzymes in the bipolar patients during lithium treatment did not differ from those in the volunteers. Thus, platelet MAO and plasma DBH activities differed in unmedicated patients with bipolar affective disorder from those of healthy subjects. Treatment with lithium appeared to have a normalizing effect on MAO and DBH activity levels.
对29例接受碳酸锂治疗的双相情感障碍患者（平均年龄=33.12岁，标准差=7.27）和20名健康志愿者（平均年龄=30.05岁，标准差=6.04）的单胺氧化酶（MAO）和多巴胺-β-羟化酶（DBH）（参与单胺代谢的酶）活性进行了研究。停药后血小板MAO活性升高，而与正常志愿者相比，病情缓解处于心境正常期的双相情感障碍患者血浆DBH活性降低。与停药时的值相比，锂治疗期间血小板MAO活性降低，血浆DBH活性升高。还观察到，锂治疗期间双相情感障碍患者这些酶的活性与志愿者的酶活性没有差异。因此，未用药的双相情感障碍患者的血小板MAO和血浆DBH活性与健康受试者不同。锂治疗似乎对MAO和DBH活性水平具有归一化作用。
