Huang L G, Bowden C L
J Clin Psychopharmacol. 1984 Dec;4(6):326-31.
Platelet monoamine oxidase (MAO) activity was studied in bipolar and schizophrenic patients treated with lithium and was found to be increased as a nonspecific drug effect. Greater MAO increase in manic patients was correlated with lesser clinical improvement. There was no correlation of MAO activity with short-term outcome in schizophrenic patients. Change in MAO was not correlated with lithium dosage or plasma levels. Patients with baseline MAO values below the median had the largest activity increases. Platelet MAO might thus be characterized as a state variable, increased by lithium as a nonspecific pharmacologic effect, with the increase associated with poor clinical outcome in manic patients.
对接受锂盐治疗的双相情感障碍和精神分裂症患者的血小板单胺氧化酶（MAO）活性进行了研究，发现其升高是一种非特异性药物效应。躁狂患者中MAO升高幅度越大，临床改善程度越小。精神分裂症患者的MAO活性与短期预后无关。MAO的变化与锂盐剂量或血浆水平无关。基线MAO值低于中位数的患者活性增加幅度最大。因此，血小板MAO可能被视为一种状态变量，锂盐作为非特异性药理效应可使其升高，且这种升高与躁狂患者不良的临床预后相关。
